Testosterone Matrix includes KSM-66® ashwagandha, a proprietary full-spectrum extract of withania root with extensive clinical research to support its use for stress-related health concerns. Through a patented alcohol-free, solvent-free extraction process that took over a decade to perfect, KSM-66® is able to retain high concentrations of both hydrophilic components and lipophilic components of the raw root. KSM-66® is unique from other ashwagandha root extracts as it has specifically been studied and shown to improve sperm parameters, muscle strength, testosterone levels in males and sexual function in females. KSM-66® also has over 20 human clinical trials to support its efficacy in areas of memory and cognition, stress reduction, improved thyroid function and weight management.
Trigonella foenum-graecum, more commonly known as fenugreek, has traditionally been used to increase milk production in breastfeeding women and as an effective tool for regulating blood sugar levels. More recent evidence has found that a particular extract of fenugreek known as Testofen®, which is standardized to a proprietary blend of saponin glycosides, can promote healthy testosterone levels in men. A double-blind, placebo-controlled clinical trial in resistance-training males aged 18-35 showed a significant increase in both total and free testosterone, by 11% and 99% respectively, after 8 weeks of supplementation. Another double-blind placebo-controlled human study used Testofen® in combination with magnesium, zinc and vitamin B6 for 6 weeks, finding significant improvements in self-rated areas of sexual arousal, orgasm, libido, quality of sexual performance, energy and overall well-being. A third trial of 120 males aged 43-70 confirmed that solo-therapy with Testofen® can effectively reduce the normal symptoms of andropause and improve sexual health by significantly increasing sexual arousal, desire and activity, as well as free and total testosterone levels.
Finally, specific nutrients have been shown to support endogenous testosterone production. Zinc’s reputation as an immune boosting mineral is well-deserved, however, it is very much indicated for healthy hormonal support. In particular, a zinc deficiency in males can negatively affect sperm parameters and it is one of the few nutrients that has been shown to contribute to low testosterone. Moreover, zinc supplementation has been demonstrated to increase free testosterone levels in men with suboptimal baseline levels and it can improve mood and cognition by increasing brain-derived neurotrophic factor and blocking NMDA receptors in the brain.
Vitamin D is the other key nutrient to play a role in regulating testosterone. While more research is needed to determine the exact relationship, serum vitamin D concentrations have been found to be a significant, positive predictor of total testosterone levels in a number of observational trials. This correlation has also been observed in women. In addition, one interventional trial found that vitamin D supplementation helped to increase testosterone levels in men with vitamin D deficiency at baseline.
All in all, Testosterone Matrix was formulated to provide evidence-based dosages of KSM-66® ashwagandha and Testofen® fenugreek, along with supportive vitamins and minerals, to optimally support healthy testosterone levels, strength, libido and cognition in males.
