Three major naturally occurring forms of estrogen in women are estrone (E1), estradiol (E2), and estriol (E3). Hormones have important functions in every area of the body. They are chemical messengers that interact with cells all over the body (especially tissues that are more sensitive to them, including breast tissue). The most important message they deliver to cells is to grow, divide, and multiply. For this reason, hormones are critically important in human development and tissue repair. Supporting estrogen synthesis and metabolism is essential for proper hormonal balance. Depending on how estrogen is metabolized it can result in different metabolites, each with individual biological activity. By keeping hormones in balance and ensuring the body is able to process hormones properly, I3C and DIM work together to reduce hormone overload. Current data on I3C and DIM, suggests that these phytonutrients have strong potential for supporting breast health.1-4 I3C* is a naturally occurring compound derived from cruciferous vegetables such as broccoli, Brussels sprouts and cabbage. Together, I3C and DIM promote the creation of the more favorable and protective 2-hydroxyestrone (2-OHE) metabolite versus production of 4-hydroxyestrone (4-OHE) and 16-alpha-hydroxyestrone (16-alphaOHE), metabolites which can overstimulate cells and create free radicals that cause DNA damage.5 The influence of I3C and DIM on estrogen metabolism creates a more desirable ratio of 2-OHE to 16-alpha-OHE. This assessment of 2:16 alpha- OHE ratio has been used to evaluate hormonal health.
Many of the health benefits derived from eating cruciferous vegetables (cabbage, Brussels sprouts, broccoli, etc.) are thought to be derived from the group of secondary metabolites known as glucosinolates. When these vegetables are cut, crushed or chewed, the actions of the enzyme myrosinase(released from the cells) hydrolyses these glucosinolates into other compounds. For instance, glucosinolates from broccoli and brussel sprouts readily convert into I3C when consumed. I3C can then be further converted via stomach acid into other health promoting compounds, including DIM. These compounds are thought to be responsible for the various cellular activities involved in hormone health.
I3C
I3C is a naturally occurring compound found in numerous cruciferous vegetables, such as broccoli, cauliflower, kale and cabbage. Following ingestion of I3C, the body converts it to several different metabolites, one of which is diindolylmethane (DIM). Both of these compounds, as well as many other I3C metabolites, have been shown to impact metabolic shifts and cellular activities for improved health outcomes. I3C has also been shown to temper estrogen signals by competing for binding sites and inhibiting the pain, jaundice) or symptoms of low estrogen. Do not use this product if you are pregnant or breastfeeding.
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DIM
DIM* is a phytonutrient and plant indole also found in cruciferous vegetables. As a dimer (formed chemical structure of two substances) of indole-3-carbinol, DIM promotes beneficial estrogen metabolism in both sexes supporting the formation of healthy estrogen metabolites.17-19
