This product is gluten-free. Consult a healthcare practitioner prior to use if you have a cardiovascular disease, a liver disorder or develop liver related symptoms, if you have stomach ulcers or excess stomach acid, gallstones or a bile duct obstruction, or if you have a history of non-melanoma skin cancer. Consult a healthcare practitioner prior to use if you have an iron deficiency or taking medications. Consult a healthcare practitioner for use beyond 12 weeks. Do not use if perma seal is missing.