Fem·Matrix

The transition into menopause can be a difficult time for many women as hormone levels dramatically and rapidly decline. Hot flushes are by far the most commonly reported symptom as the body’s thermoregulatory system becomes poorly controlled with blood vessel dilation in the skin. However, hormonal changes can also cause changes in mood such as anxiety or depression, as well as cognitive adjustments that present as poor concentration, memory and attention. While exercise and a healthier diet have been proven as integral strategies to ease these symptoms, many natural treatments can also help with the menopausal transition.


Phytoestrogenic herbs such as angelica sinensis, actaea racemosa and trifolium pretense have demonstrated various reductions in hot flashes and menopausal symptoms, partly as a result of their ability to weakly bind estrogen receptors. Actea racemosa also has phytoestrogenic activity but may act more centrally on the brain and positively affect serotonin, dopamine or opiods. Although mixed research exists for the effectiveness of phytoestrogenic herbs in treating hot flushes, positive trials tend to favour extracts with standardized active ingredients or higher potency.


Other herbs can be beneficial in easing menopausal symptoms because of mechanisms outside of estrogen. For example, vitex agnus-castus, commonly known as chastetree, acts more as a progesterogenic herb while diascorea villosa is a well-known antispasmodic herb. Hypericum perforatum is best known for its ability to regulate mood and improve symptoms of depression but it has also been demonstrated to reduce the severity of hot flushes in menopausal women.


Fem·Matrix by Cyto-Matrix combines a blend of these research-driven herbs to reduce symptoms of perimenopause and menopause, including hot flashes. Each herb is in a highly-extracted form and standardized to active ingredients to ensure potency and effectiveness. Fem·Matrix also includes the bioflavonoids quercetin and hesperidin to improve the integrity of blood vessels and reduce hot flashes

Unit of Measure above: Each capsule
Ingredient Amount
Hesperidin (fruit, Citrus aurantium) 125mg
Quercetin (flower, Styphnolobium japonicum) 125mg
Dong quai (root, Angelica sinensis) 4:1 extract equivalent to 240mg dried root, standardized to 1% ligustilides 60mg
PhytoProof® Black cohosh (root and rhizome, Actaea racemosa) 6:1 extract equivalent to 300mg dried root and rhizome, standardized to 2.5% triterpene glycosides 50mg
Chasteberry (fruit, Vitex agnus-castus) 10:1 extract equivalent to 500 mg dried fruit 50mg
Wild yam (root, Dioscorea villosa) 10:1 extract equivalent to 500mg dried root 50mg
St. John's wort (herb top, Hypericum perforatum) 10:1 extract equivalent to 200mg dried herb top, standardized to 0.3% hypericin 30mg
Red clover (flower, Trifolium pratense) 10:1 extract equivalent to 200mg dried flower 20mg
* PhytoProof® is a registered trademark of Euromed USA, Inc.

Non-Medicinal Ingredients:
Hypromellose, magnesium stearate, microcrystalline cellulose, silicon dioxide.

Indications:
Black Cohosh is used in Herbal Medicine to help relieve symptoms associated with menopause. Black Cohosh is used in Herbal Medicine to help relieve premenstrual symptoms. Wild Yam is Traditionally used in Herbal Medicine as an antispasmodic to relieve abdominal and menstrual pain.



Directions for Use:
Adults (18 years and older) - Take 2 capsules, 2 times per day with food. Consult a healthcare professional for use beyond 12 weeks.



Cautions:
Do not use if • you are pregnant • you are breastfeeding • you are taking anti-cancer medications • you are taking blood thinners/antidepressants medications (e.g selective serotonin reuptake inhibitors (SSRI)) • you are taking anti-HIV agents • you are taking cardiovascular medications • you are taking immunosuppressants • you are taking contraceptive medications • you have diarrhea • you have hemorrhagic diseases • you have hypermenorrhoea/profuse menstrual flow/heavy periods • you have an allergy/hypersensitivity to members of the Apiaceae/Umbelliferae family (anise, caraway, carrot, celery, dill, parsley). Stop use and consult a healthcare professional if • menstruation is delayed or absent • you experience increased menstrual bleeding time • you experience breast pain, discomfort and/or tenderness. Hypersensitivity, such as an allergy, has been known to occur; in which case, discontinue use. Consult a healthcare professional if • you have a family history of cancer • you have a liver disorder or develop symptoms of liver trouble. Consult a healthcare professional if you are taking • any prescription medications • anti-anxiety medications • seizure medications • antihistamines • bronchodilators • muscle relaxants • opiates • hormone-containing medications such as progesterone preparations, oral contraceptives, birth control pills or hormone replacement therapy. Some people may experience mild gastrointestinal disturbances, nausea, restlessness and/or headaches. Consult a healthcare professional if symptoms persist or worsen. Avoid prolonged exposure to sunlight, ultraviolet light (UV) or UV therapy. Keep out of reach of children.



Known Adverse Reactions: Discontinue use and consult a healthcare professional if you experience breast pain, discomfort and/or tenderness. Hypersensitivity, such as an allergy, has been known to occur; in which case, discontinue use. Some people may experience mild gastrointestinal disturbances, nausea, restlessness and/or headaches.