AOR I-3-C

ndole-3-carbinol (I-3-C) is a phytonutrient found in Brassica vegetables such as broccoli, kale and cabbage, and is one of the key health-promoting compounds in these foods.

To understand benefits we must first consider estrogen. “Estrogen” is actually not one substance, but a family of forms: E1, E2 and E3 that stimulate the growth and development of women’s reproductive systems. These forms all undergo metabolism in the liver which can yield different end products or metabolites. The estrogen metabolite 16 alpha-hydroxyestrone (16OHE) is a “bad” estrogen as it can increase risk of damaging cells. On the other hand, “good” estrogens also exist, in the form of 2-hydroxyestrone (2OHE), along with 2-methoxyestradiol. The idea is to encourage the body to favour detoxification into these less harmful pathways and then ensure proper packaging and excretion of these “old” hormones.

Human studies in women taking I-3-C have shown a favourable shift in estrogen metabolism.

AOR Advantage
AOR’s I-3-C provides a safe and effective dose of this natural ingredient.

I3C vs DIM
I3C needs stomach acid to then convert into 15+ compounds, of which the most predominant is DIM. While there are advantages for supplementing with DIM directly (in individuals with poor stomach acid conversion), some may want to take this parent molecule for the synergy of the other compounds produced.

Serving Size One Capsule

Indole-3-Carbinol (I3C)200 mg
Non-medicinal Ingredients*: Microcrystalline cellulose. Capsule: Hypromellose.

*NMIs are subject to change. Always read and follow the label for accurate ingredient and allergen information.

Adult Dosage
Adults (18 years and over) – Take one capsule one to two times daily with or without food, or as directed by a qualified health care practitioner. Do not crush, mix or blend capsules. Swallow capsules whole. Do not exceed daily dose unless instructed by a healthcare practitioner.

Cautions
Do not use if you are pregnant or breastfeeding. Consult a health care practitioner before use to exclude the diagnosis of a serious cause of hormonal imbalance, if you are taking any medications or natural health products or if you are attempting to conceive, (for female subpopulation): if you have a liver disorder or symptoms of low estrogen such as joint pain, mood changes, changes in libido, hot flashes, night sweats, vaginal dryness or irregular menstruations; (for male subpopulation): if you have a liver disorder or symptoms of low estrogen such as joint pain, mood changes or changes in libido. Stop use and ask a health care practitioner if you develop liver-related symptoms (e.g., abdominal pain, jaundice) or symptoms of low estrogen.

Main Applications
Estrogen metabolism
Estrogen balance
Women’s health
Antioxidant support
Disclaimer
The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide or replace medical advice to individuals from a qualified health care professional. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes.